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New biocompatible CaF2 fluidic devices for FTIRM based on SU-8 resist: a new chemically assisted thermo-mechanical bonding

Mild bonding conditions discussed are compatible with fragile and unconventional materials, but the protocol can be effortlessly extended to quartz, glass or silicon. Since the applicability of the protocol is general it can either impact on the other imaging techniques that require optical paths completely free from any polymeric material, or be applied to the fabrication of multilayer SU-8 devices. â€¨

E. Mitri  et al. Analyst 138, 4015 (2013) 

A new bonding protocol for the fabrication of SU-8 based devices has been developed. Thanks to the formation of additional dangling bonds on already lithographed SU-8 layers by exposure to 254 nm UV light, the chemical bonding is achieved with a mild thermo-mechanical process using low temperatures and moderate pressures. The optimized process was applied for the fabrication of CaF2 microfluidic devices transparent to light from UV to mid-IR, where SU-8 is used as structural material and the optical path is free from polymeric residues.   Thanks to their biocompatibility, the fluidic chips have been used for FTIRM studies of living cells. We identified infrared biomarkers of the lytic process of MCF-7 breast cancer cells, induced by osmotic stress, proving the usefulness of these devices for following cellular dynamics.

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SU-8 bonding protocol for the fabrication of microfluidic devices dedicated to FTIR microspectroscopy of live cells;
E. Mitri  et al.
Analyst 138, 4015 (2013)



Last Updated on Wednesday, 01 October 2014 10:23